Physical activity builds physical vitality. With every year of your life, you have more to gain from being physically active. As your age-related risks of chronic disease increase, regular physical activity generally slows that trend. Some research suggests that the heart and blood vessel (cardiovascular) benefits you get from physical activity may also help your brain stay healthy. In fact, you're even more likely to notice the benefits of regular physical activity if you already have a chronic condition, such as depression, coronary artery disease, or diabetes.